Our Solution
NEUROFUSE is a fully non-invasive,
AI-driven system designed to identify
and regulate the brain-network metabolic patterns that sustain chronic pain.
Core Concept
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Chronic pain is linked to:
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Mitochondrial dysfunction
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Reduced ATP availability
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Redox imbalance
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Reinforced excitatory synaptic transmission
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These processes leave detectable metabolic and network-level signatures
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NEUROFUSE targets signatures, not symptoms.
How NEUROFUSE Works
1. Metabolic Imaging
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Advanced MRSI measures spatial patterns of cellular energy stress
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Features extracted via a 3D Masked Autoencoder
2. Network Modeling
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Brain modeled as a graph
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Nodes = regions
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Edges = connectivity
3. Graph Intelligence
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GIN: compares a region’s metabolism relative to its neighbors
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GAT: identifies nodes whose dysfunction propagates most strongly
4. Fusion & Ranking
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Cross-attention transformer fuses metabolism + network data
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Outputs a ranked list of intervention targets
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Targets are selected based on patient-specific brain states, not fixed anatomical locations.